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hematology neurology guillain anemia aplastic apml comatose differentiation encephalopathy gbs guillainbarre hemeonc hemophagocytic hlh leukostasis lymphohistiocytosis lysis posterior pres reversible
Guillain-Barre Syndrome - Summary Acute AIDP that presents with rapidly progressive flaccid weakness Epidemiology: • 1-2 cases/100,000 per
Guillain-Barre Syndrome ... Pathophysiology ... Diagnosis: • ... #Syndrome #diagnosis ... #management #treatment
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
Guillain-Barré Syndrome ... Incidence: 1 to 2 cases ... the underlying pathophysiology ... #Syndrome #diagnosis ... #management #neurology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Incidence: common in APL ... ATRA treatment Pathophysiology ... #management #hematology ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... CMV) • Epstein-Barr ... Aplastic #Anemia #oncology ... #hematology #diagnosis ... #management
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... high WBC count cause ... have fever - ACS ... #TLS #diagnosis ... #management #hematology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Etiology: • Pathophysiology ... circulation: MCA ACA ... the underlying cause ... with AEDs until cause ... #diagnosis #management
The Neurological Evaluation of a Comatose Patient Definition: • Coma: a state of unresponsiveness; the absence of
Differential Diagnosis ... • Locked-in syndrome ... • Mutism Pathophysiology ... Casey Albin MD @ ... caseyalbin #PhysicalExam
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... caused by uncontrolled ... • In all patients ... with the HLH syndrome ... Pathophysiology
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