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diagnosis differential causes hyperkalemia algorithm hypokalemia management high low pharmacology rhabdomyolysis treatment acutekidneyinjury aki diuretics gitelman hormones kidney locations medications
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
• Increased EC shift ... differential #diagnosis #pathophysiology ... #pharmacology #potassium ... #medications #druginduced
Drug-Induced Acute Kidney Injury - Sites of Action Along the Nephron #DrugInduced #AcuteKidneyInjury #AKI #Nephrology #Pathophysiology #Pharmacology
the Nephron #DrugInduced ... AcuteKidneyInjury #AKI #Nephrology ... #Pathophysiology
Hypokalemia - Differential Diagnosis Algorithm Transcellular Shift: • Alkalosis • ↑ beta-2 adrenergic simulation • Erythropoiesis
Transcellular Shift ... Transcellular shifts ... Diagnosis #Algorithm #nephrology ... #low #potassium
Causes of Hyperkalemia - Differential Diagnosis Algorithm • Increased Intake • Reduced Excretion (IV potassium with
Excretion (IV potassium ... Transcellular Shift ... #Hyperkalemia #Nephrology
Hyperkalemia Treatment Options Stabilize cardiac membrane: • IV Calcium (peaks 5-10 minutes) Decrease potassium concentration: • IV Fluids Shift
minutes) Decrease potassium ... • IV Fluids Shift ... potassium intracellularly ... Sodium bicarbonate Potassium ... #nephrology
Causes of Hypokalemia - Differential Diagnosis Algorithm Increased Loss - Increased GI Loss - Increased Urinary
Transcellular Shift ... Algorithm #causes #potassium ... #low #pathophysiology
Hormones Acting on the Nephron - Diuretics and Their Site of Action 1) Acetazolamide 2) Osmotic
HCTZ) 5) Potassium-sparing ... spironolactone) #Pathophysiology ... #Nephrology #Nephron
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine Urine K+
the basis of the potassium-to-creatinine ... creatinine) • Cell shift ... hypokalemia #urine #potassium ... algorithm #diagnosis #nephrology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
• Recent IV potassium ... Intracellular Shift ... diagnosis #causes #potassium ... #high #nephrology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
• Recent IV potassium ... Intracellular Shift ... diagnosis #causes #potassium ... #high #nephrology
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