10 results
diagnosis differential causes hyperkalemia management hypokalemia algorithm high rhabdomyolysis treatment gitelman hormones kidney locations low medications nephron pharmacology siteofaction summary
Hypokalemia - Differential Diagnosis Algorithm Transcellular Shift: • Alkalosis • ↑ beta-2 adrenergic simulation • Erythropoiesis
Transcellular Shift ... Transcellular shifts ... • Discontinued diuretic ... Diagnosis #Algorithm #nephrology ... #low #potassium
Hormones Acting on the Nephron - Diuretics and Their Site of Action 1) Acetazolamide 2) Osmotic
the Nephron - Diuretics ... HCTZ) 5) Potassium-sparing ... spironolactone) #Pathophysiology ... #Nephrology #Nephron ... #Diuretics #Hormones
Hyperkalemia Treatment Options Stabilize cardiac membrane: • IV Calcium (peaks 5-10 minutes) Decrease potassium concentration: • IV Fluids Shift
minutes) Decrease potassium ... • IV Fluids Shift ... potassium intracellularly ... function) - Loop diuretic ... #nephrology
Mechanisms of Drug-Induced Hyperkalemia • Direct renin inhibitor (Aliskiren) • Renin release inhibition (NSAIDs, Beta-Blockers)
• Increased EC shift ... differential #diagnosis #pathophysiology ... #pharmacology #potassium ... #medications #druginduced
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine Urine K+
the basis of the potassium-to-creatinine ... creatinine) • Cell shift ... Urine Cl - Loop diuretics ... , Thiazide diuretics ... algorithm #diagnosis #nephrology
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
• K sparing diuretics ... • Recent IV potassium ... Intracellular Shift ... diagnosis #causes #potassium ... #high #nephrology
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
Dermatomyositis) AKI - Pathophysiology ... Shift of extracellular ... Monitor potassium ... Loop diuretics for
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
• K sparing diuretics ... • Recent IV potassium ... Intracellular Shift ... diagnosis #causes #potassium ... #high #nephrology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Shift of extracellular ... Monitor potassium ... Loop diuretics for ... causes #treatment #nephrology
Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
with thiazide diuretic ... Surreptitious diuretic ... Supplement: • Potassium ... Syndrome #diagnosis #nephrology ... #management #pathophysiology
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