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hematology reactions sle treatment blood druginduced erythematosus product systemic transfusion classification comparison complications cryoglobulins dil hemophagocytic hlh lymphohistiocytosis muscle myopathy
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... Summary • Epidemiology ... Manifestations: Malar ... #Management #Summary ... #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Summary Cryoglobulins ... causing endothelial injury ... Labs/Diagnosis: ... (e.g. systemic lupus ... classification #rheumatology
Systemic Lupus Erythematosus - Summary Antinuclear (ANA) - 95% - Initial screening test Anti-dsDNA - 50% • Associated
Systemic Lupus Erythematosus ... - Summary Antinuclear ... #Systemic #Lupus ... #diagnosis #rheumatology ... #management
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
& NPSLE rare, Malar ... Manifestations: Malar ... Usual therapeutic management ... comparison #table #rheumatology ... #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Auto-amplification loop Diagnosis ... Leishmaniosis, malaria ... Lymphohistiocytosis #diagnosis ... #management #treatment ... #summary #rheumatology
Statin Induced Muscle Toxicity - Summary Clinical Presentation: • Elevations of serum creatine kinase with proximal myalgia
Muscle Toxicity - Summary ... GBS), systemic lupus ... Direct muscle injury ... Risk of muscle injury ... #management #treatment
Transfusion Reactions - Summary Cheatsheet • Hemolytic Reaction • Febrile Reactions • Transfusion Related Acute Lung
Transfusion Reactions - Summary ... Related Acute Lung Injury ... Transfusion #Reactions #diagnosis ... #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Transfusions One Pager Summary ... Related Acute Lung Injury ... tested include: Malaria ... #Transfusions #diagnosis ... #management #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Related Acute Lung Injury ... tested include: Malaria ... #Transfusion #diagnosis ... #management #hematology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
Drug Induced Lupus ... & NPSLE rare, Malar ... #DIL #rheumatology ... #diagnosis #treatment ... #management
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