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diagnosis differential hematology erythematosus sle agglutinin algorithm autoantibodies causes classification disease extravascular hodgkins infectiousdiseases intravascular lymphoma management mimickers oncology signs
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Framework for Hemolysis ... Intravascular Hemolysis ... Microangiopathic hemolytic ... usually IgG) (e.g. lupus ... • Infections: Malaria
SLICC SLE Diagnostic Criteria - Systemic Lupus Erythematosus Clinical and Immunologic Criteria CLINICAL CRITERIA - ACUTE CUTANEOUS LUPUS
NEUROLOGIC - HEMOLYTIC ... ANEMIA - LEUKOPENIA ... reference range (or 2-fold ... the absence of hemolytic ... #Rheumatology #
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Agglutination - Cold ... bartonella (oroya fever ... elliptocytosis, autoimmune hemolysis ... ARUPConsult @ARUPLabs #Hemolytic
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Diagnosis: • hemolytic ... • Compensated hemolysis ... intravascular hemolysis ... agglutinin #disease #hemolytic ... #anemia #hematology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Arthritis 69% - Malar ... rash 40% - Fever ... Lymphadenopathies 7% - Hemolytic ... anemia 4% - Myositis ... #differential #rheumatology
Fever After International Travel Infectious Disease: • Endemic in either the destination or home region Viral Syndromes: Arboviral infections, a
No hemolytic anemia ... Babesiosis • Plasmodium ... Most cases of malaria ... and myalgias, symptoms ... • Falciparum malaria
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Dyspnea • Fever ... nodosum • Immune hemolytic ... anemia • Pain ... ingestion • B symptoms ... through Ann Arbor criteria
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