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diagnosis differential hematology management druginduced erythematosus hemolytic oncology purpura systemic thrombocytopenia workup algorithm autoantibodies bruising classification comparison dermatology dil extravascular
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
and Platelet Disorders ... pylori test (GI symptoms ... test, ANA (e.g., SLE ... changes), high MCV anemia ... #Workup #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
PURPURA: Platelet ... - Hemolytic anemia ... Splenomegaly - CTD (SLE ... Associated - SLE ... #rheumatology #
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms ... & NPSLE rare, Malar ... constitutional symptoms ... Manifestations: Malar ... #table #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Arthritis 69% - Malar ... - Hemolytic anemia ... Lupusreference #SLE ... autoantibodies #signs #symptoms ... #differential #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... usually IgG) (e.g. lupus ... lymphoproliferative disorders ... • Infections: Malaria ... #anemia
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... genotypes): SS, SC, SE ... with or without platelet ... suspected, consider malaria ... Consider RBC membrane disorder
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... thrombocytopenia) - SLE ... (systemic lupus ... bypass Vascular disorders ... Purpura #Bruising #Causes
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Non-autoimmune rheumatologic ... Photosensitivity • Malar ... lymphopenia, low PLT • Anemia ... : • Symptoms limited
Hematology Algorithms Anemia is described as a reduction in the proportion of the red blood cells.
Hematology Algorithms ... experience some symptoms ... 13 g/dL in men, platelets ... that involves disorders ... These causes could
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... caused by blood ... age 70 years Symptoms ... skin that are caused ... Disorders • Nutritional
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