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diagnosis differential blood erythematosus management product reactions sle symptoms systemic algorithm autoantibodies extravascular hemolysis infectiousdiseases intravascular mimickers transfusion transfusions travel
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... usually IgG) (e.g. lupus ... • Infections: Malaria ... differential #diagnosis #hematology ... #anemia
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... suspected, consider malaria ... bartonella (oroya fever ... Algorithm #workup #hematology ... #testing
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Arthritis 69% - Malar ... rash 40% - Fever ... anemia 4% - Myositis ... autoantibodies #signs ... #differential #rheumatology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... (SLE) General: Fever ... ) Blood (75%): Anemia ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Fever After International Travel Infectious Disease: • Endemic in either the destination or home region Viral Syndromes: Arboviral infections, a
No hemolytic anemia ... Babesiosis • Plasmodium ... malaria • Enteric ... polymerase-chain-reaction (PCR) testing ... and possibly PCR testing
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
S/sx: Fever, flank ... Causes purpura & ... false negatives on testing ... tested include: Malaria ... diagnosis #management #hematology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Crossmatch - involves testing ... S/sx: Fever, flank ... false negatives on testing ... tested include: Malaria ... diagnosis #management #hematology
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