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diagnosis systemic erythematosus sle symptoms differential workup hemolytic algorithm arthritis autoantibodies causes disease extravascular gout hemolysis intravascular laboratory management mimickers
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Systemic Lupus Erythematosus ... Arthritis 69% - Malar ... - Hemolytic anemia ... autoantibodies #signs ... #differential #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... usually IgG) (e.g. lupus ... • Infections: Malaria ... differential #diagnosis #hematology ... #anemia
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... suspected, consider malaria ... ARUPLabs #Hemolytic #Anemia ... Algorithm #workup #hematology ... #testing
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... ) Blood (75%): Anemia ... Thrombocytopenia #Lupus ... erythematosus #signs ... symptoms #diagnosis #rheumatology
Systemic Lupus Erythematosus (SLE) - Typical Signs/Symptoms Alopecia, Fever, Malar rash, Photosensitivity, Adenopathies, Lupus pneumonia, Pleurisy, Pancreatitis,
SLE) - Typical Signs ... Alopecia, Fever, Malar ... Adenopathies, Lupus ... Erythematosus #SLE #Signs ... Symptoms #diagnosis #rheumatology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
elbows/wrists and knees ... skin thickening Signs ... Scleroderma #SSc #rheumatology ... #diagnosis #signs ... #symptoms #testing
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... Malignancy (e.g. hematologic ... Photosensitivity • Malar ... lymphopenia, low PLT • Anemia ... Erythematosus #Diagnosis #Rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases • Septic arthritis - Gram stain and culture of
Rheumatology Workup ... joint • Systemic lupus ... - CCP antibody testing ... the presence of anemia ... #Rheumatology
Gout - Diagnosis and Management Summary 3 Conditions for Gout to Manifest: 1. Hyperuricemia 2. Monosodium urate deposition in
forefoot, ankles, knees ... Synovial Fluid Testing ... double contour sign ... +Radiographic signs ... management #treatment #rheumatology
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