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management differential sle arthritis erythematosus symptoms systemic treatment vasculitis classification comparison dermatology dermatomyositis druginduced msk table anemia antimda5 antimda5dm antinxp2
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
(SLE) - Diagnosis ... and Management Summary ... Manifestations: Malar ... Positive in 60-80% of cases ... #rheumatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
- Diagnosis Manifestations ... Arthritis 69% - Malar ... Differential Diagnosis ... autoantibodies #signs ... #differential #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... usually IgG) (e.g. lupus ... • Infections: Malaria ... #hematology #anemia
Systemic Lupus Erythematosus (SLE) - Typical Signs/Symptoms Alopecia, Fever, Malar rash, Photosensitivity, Adenopathies, Lupus pneumonia, Pleurisy, Pancreatitis,
SLE) - Typical Signs ... Alopecia, Fever, Malar ... Erythematosus #SLE #Signs ... #Symptoms #diagnosis ... #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
& NPSLE rare, Malar ... Discontinuation of causal ... Manifestations: Malar ... comparison #table #rheumatology ... #diagnosis #management
Rheumatoid Arthritis Summary Overview: chronic, inflammatory symmetric polyarthritis involving small joints of hands/feet, knees, shoulders Signs & Symptoms:
Rheumatoid Arthritis Summary ... hands/feet, knees, shoulders ... Signs & Symptoms ... : CLINICAL DIAGNOSIS ... #management #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Auto-amplification loop Diagnosis ... Leishmaniosis, malaria ... Drugs, Unknown cause ... management #treatment #summary ... #rheumatology
Features That Differentiate Acute Pericarditis from Myocardial Ischemia or Infarction and Pulmonary Embolism In contrast to the
associated with rheumatologic ... presentation of systemic lupus ... trapezius ridges or shoulders ... life-threatening causes ... comparison #Table #Diagnosis
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 Polycythemia Vera (PV) - Diagnosis and Management Summary Diagnostic Criteria: • Elevated hemoglobin and/or hematocrit AND •
and Management Summary ... present, symptoms, signs ... aspirin • Aspirin should ... #Management #Summary ... #treatment #hematology
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
chest (in a V-sign ... , and back and shoulders ... (in a shawl sign ... Dermatomyositis #rheumatology ... #dermatology #diagnosis
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