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diagnosis management erythematosus systemic arthritis differential druginduced hemophagocytic hlh lymphohistiocytosis rheumatoid summary thrombocytopenia workup activation ana antibodies antinuclear cerebritis chronic
Systemic Lupus Erythematosus (SLE) - Diagnosis and Management Summary • Epidemiology: 10-180/100,000, Typically Age 20-40, F:M
Systemic Lupus Erythematosus ... 40, F:M 9:1 • Clinical ... Manifestations: Malar ... life-threatening • Treatment ... Management #Summary #rheumatology
Skin Conditions Associated with Joint Pain Rash • Human parvovirus B19 infection Malar rash • SLE • Human parvovirus B19 infection •
Malar rash ... • SLE • Human ... IBD • RA • SLE ... lesions • Discoid lupus ... differential #diagnosis #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Erythematosus (SLE ... ) Clinical Manifestations ... Cerebritis Induction ... Erythematosus #SLE ... CNS #neurology #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... & NPSLE rare, Malar ... 40, F:M 9:1 • Clinical ... Manifestations: Malar ... #table #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
healthy adults, and should ... likely it will be clinically ... erythematosus (SLE ... Lymphoproliferative Disorders, Infection ... ANA #patterns #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... ) Suspect: Clinical ... Non-autoimmune rheumatologic ... Photosensitivity • Malar ... Erythematosus #Diagnosis #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... Assessment • Clinical ... Leishmaniosis, malaria ... Autoimmune diseases: SLE ... #summary #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
SJIA], systemic lupus ... erythematosus [SLE ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
Holistic Management of Systemic Lupus • Lifestyle interventions: Smoking cessation, Photoprotection, Therapeutic adherence, Anxiety/depression/fatigue, Fibromyagia/pain management,
Management of Systemic Lupus ... #holistic #SLE ... #Systemic #Lupus ... Erythematosus #management #treatment ... #rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Syndrome: • Clinical ... diseases: - 10% SLE ... (e.g. systemic lupus ... erythematosus (SLE ... classification #rheumatology
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