271 results
Major Clinical Trials and Evidence Summary for Transfusion Thresholds in Critical Care

TRICC - NEJM 1999 -
Evidence Summary for Transfusion ... unnecessary and cause ... Unnecessary transfusions ... Transfusions should ... Transfusions are
Indications for Transfusion
Packed RBCs
 • Hgb <7 g/dL or hematocrit <21% in a patient with uncompromised
Indications for Transfusion ... hemoglobinopathy Platelets ... not transfuse platelets ... Platelet transfusions ... Willebrand disease #Transfusion
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
donor (apheresis) platelets ... , due to anti-platelet ... Causes purpura & ... TRALI): Leading cause ... more likely to cause
Thresholds for Transfusion of Platelets in Adults
Major surgery or invasive procedure, no active bleeding - 
≤
Thresholds for Transfusion ... of Platelets in ... 100 (rarely) Stable ... #Management #Platelets ... #Transfusion #Plateletpheresis
Indications for Transfusion of Platelets in Neonates

#Management #Peds #Pediatrics #Platelets #Transfusion #Plateletpheresis #Thresholds #NonBleeding #Surgery
Indications for Transfusion ... of Platelets in ... Peds #Pediatrics #Platelets ... #Transfusion #Plateletpheresis
Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
 • Defect of adhesion due to a lack of GP Ib/IX/V
Inherited Qualitative Platelet ... Single isolated platelets ... without platelet ... failure Grey Platelet ... Defects #comparison #table
Thromboelastography (TEG) based therapy and Management

If r time prolonged -> FFP
If MA low -> plts/cryoprecipitate (if
cryoprecipitate If platelets ... < 50 - > platelet ... transfusions If
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
, due to anti-platelet ... Causes purpura & ... TRALI): Leading cause ... common following platelet ... more likely to cause
Thromboelastography (TEG) Based Management
 - If R time prolonged -> FFP 
 - If MA low
cryoprecipitate - If platelets ... < 50 -> platelet ... transfusions
Thrombocytosis - Differential Diagnosis
Platelet Count > 450
Reactive:
 • Anemia/blood loss (Fe deficiency)
 • Infection/Sepsis
 • Non-infectious
Differential Diagnosis Platelet ... Differential #Diagnosis #causes ... #Platelets #hematology