11 results
Vasopressors and Inotropes - Pharmacology Summary
Vasopressors
Phenylephrine (alpha-1)
 • Increases BP, SVR
 • Risk of reflex bradycardia
- Pharmacology ... • Higher doses cause ... cAMP/cGMP • Causes ... #Pharmacology # ... Summary #management
Vasopressors Table 
Rough properties by Target Receptor, Heart Rate/Inotropy, Systemic Vascular Resistance, Cardiac Output, Blood Pressure,
Receptor, Heart Rate/Inotropy ... Resistance, Main Uses ... Properties #Table #Pharmacology ... #Effect #Management ... #Comparison #Inotropes
Common Vasopressors and Inotropes
Norepinephrine (NE)
 - Indication: Distributive shock (1st line for septic shock), Cardiogenic shock
Vasopressors and Inotropes ... is not desired (e.g ... is not desired (e.g ... #Vasopressors #Inotropes ... comparison #table #pharmacology
Clozapine Toxicology
Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant
Clozapine Toxicology ... distribution (1.6 – 7 L/kg ... Clozapine is known to cause ... #Toxicity #Diagnosis ... #Pharmacology
Hydroxychloroquine is an antimalarial & DMARD (disease modifying antirheumatic drug). It is currently being discussed as
(e.g. headache, ... tinnitus) and may cause ... It also can cause ... prolonging drugs (e.g ... Hydroxychloroquine #HCQ #Pharmacology
Toxic Alcohol Ingestion: Methanol
Solvent found in cleaning and printing solutions, adhesives, stains, paint removers,
antifreeze agent in
gasoline additive Pharmacology ... - Metabolite (eg ... toxicity, but does ... #Diagnosis #Management ... #Toxicology #Methanol
Hypotension - Guidelines for Crises in Anaesthesia

Hypotension is commonly due to unnecessarily deep anaesthesia, the autonomic
the autonomic effects ... and positioning (e.g ... Local anaesthetic toxicity ... (eg steroid dependency ... Checklist #Diagnosis #Management
Histamine Fish Toxicity - Inadequate refrigeration increases enzyme from bacteria on fish 
Clinical 
• Skin flushing,
Histamine Fish Toxicity ... Oral burning, nausea ... eating fish Management ... Antihistamines (e.g ... #Toxicology #Diagnosis
Amiodarone Induced Lung Toxicity Summary

Who?
• 5% of patients
• Dose ≥ 400 mg per day

How?  Possible
(e.g., acute respiratory ... (e.g., chronic ... Exclude other causes ... Pulmonary #diagnosis #management ... #Toxicology
Fomepizole for Acetaminophen Toxicity

 • In cases where fomepizole and NAC were administered together, evidence has
Acetaminophen Toxicity ... over 500-600 mg/kg ... Acetaminophen #Toxicology ... #pharmacology # ... management