17 results
SGLT2 Inhibitors - Pharmacology Summary
Mechanisms of Action: Inhibits SGLT2 (sodium/glucose cotransporter 2) in the proximal tubule,
SGLT2 Inhibitors ... - Pharmacology ... Summary Mechanisms ... #Pharmacology # ... Summary #DM2 #diabetes
DPP-4 Inhibitors - Pharmacology Summary
Mechanisms of Action: Inhibits DPP-4 (dipeptidyl peptidase 4), which normally inactivates GLP-1
- Pharmacology ... Summary Mechanisms ... not definitively cause ... #Pharmacology # ... Summary #DM2 #diabetes
Metformin Pharmacology Summary
Mechanisms of Action:
 • Suppresses gluconeogenesis by the liver
 • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... Summary Mechanisms ... agent • Does not cause ... side effects (e.g ... #Summary #DM2 #
Vasopressors and Inotropes - Pharmacology Summary
Vasopressors
Phenylephrine (alpha-1)
 • Increases BP, SVR
 • Risk of reflex bradycardia
and Inotropes - Pharmacology ... Summary Vasopressors ... • Higher doses cause ... Phosphodiesterase inhibitor ... cAMP/cGMP • Causes
GLP-1 Receptor Agonists - Pharmacology Summary
Mechanisms of Action: Stimulate glucose-dependent insulin release from the pancreas (GLP-1
Receptor Agonists - Pharmacology ... Summary Mechanisms ... side effects (e.g ... not definitively cause ... #Summary #DM2 #
SGLT2 Inhibitors 
SGLT2 inhibitors are the newest class of anti-diabetic medications, with the first one (Canagliflozin)
SGLT2 Inhibitors ... SGLT2 inhibitors ... kidney), which causes ... #Pharmacology # ... Medications #DM2
Diabetes Mellitus Type 2 Inpatient Medication Guide

Classes: Biguanide, Sulfonylurea, TZD, DPP-4 inhibitor, GLP-1 receptor agonist, SGLT2i,
Medication Guide Classes ... α-glucosidase inhibitor ... 0.3-0.6 units/kg ... Diabetes #Mellitus #DM2 ... #Medications #pharmacology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Drugs, Unknown cause ... Etoposide/VP16 (100 mg/m2 ... , ICU in case of ... Anti-IFN-y and JAK inhibitors ... management #treatment #summary
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
SAPHO Syndrome Summary ... Rule out other causes ... antiinflammatory properties e.g ... , IL-17 inhibitors ... , and IL-23 inhibitors
Myasthenia Gravis - Summary
 • an autoimmune disease of the postsynaptic neuromuscular junction associated with antibodies
Myasthenia Gravis - Summary ... serologic, and EMG ... More likely to cause ... cholinesterase inhibitor ... glucocorticoids - can cause