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hematology differential abnormal algorithm bleeding blood product prolonged pt reactions treatment aclf activation aih autoimmune chronic cirrhosis dic dili disseminated
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Diagnosis Algorithm ... Rare • Drugs (e.g ... Iatrogenic) • Liver ... #Hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Early liver disease ... Reduced liver synthesis ... #diagnosis #differential ... #hematology #coagulation
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Kidney Failure Coagulation ... Injury (DILI) ... Failure #Cirrhosis #Hepatology ... #diagnosis
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... the PT and the aPTT ... • Reduced liver ... #diagnosis #differential ... #hematology #coagulation
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
malignancy (Especially acute ... DIC • Severe Liver ... #diagnosis #causes ... #treatment #management ... #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Bleeding and Bruising ... - Differential Diagnosis ... discern these causes ... disease • Acute ... #Hematology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis ... for alternative causes ... dechallenge • Acute ... #Injury #Diagnosis ... #Algorithm #hepatology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
mixing study (aPTT ... normal in mild cases ... hemophilia type (e.g ... severity Treatment - Acute ... #hematology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
subclinical disease to acute ... liver failure ... injury, though ... Viral) Management ... #Management #Hepatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
manifestations: from easy bruising ... thrombocytopenia • Liver ... Hypofibrinogenemia • ↑ PT ↑ PTT ... Activation #Syndrome #Diagnosis ... #Management #Hematology
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