56 results
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Associated with Joint ... Pain Rash ... #joint #pain #skin ... #differential #diagnosis ... #rheumatology
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... Generally affects long ... BrighamChiefs #Bone #Joint ... #differential #diagnosis ... #causes #hematology
Thalassemia - Electrophoresis - Comparison Table
In this disorder it is the defective production of hemoglobin that
Electrophoresis - Comparison ... The main types are ... #Alpha #Beta #Comparison ... #Table #Hematology ... Electrophoresis #Diagnosis
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
Rheumatica • Pain ... Diffuse muscle pain ... and/or joint aches ... #differential #diagnosis ... #comparison #rheumatology
Thrombotic Microangiopathy - TTP VS HUS

Big picture points : Often hard to differentiate the two entities,
Big picture points ... thrombocytopenia #Comparison ... #Diagnosis #Table ... #Hematology
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
Pain History ... : Is the pain from ... Disease: • Pain ... #Pain #MSK #rheumatology ... #differential #diagnosis
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY

RED FLAGS - In all cases there are specific
markers which
Malignancy - Night pain ... neurology, back pain ... Haematology - ... discrepancy, multiple joint ... Peds #Pediatrics #Diagnosis
Adrenal Insufficiency - Diagnosis and Management Summary
Primary Adrenal Insufficiency:
Most Common Cause in the US: Autoimmune Adrenalitis
Other
adrenoleukodystrophy, check point ... anorexia, abdominal pain ... pain (10-40%), ... Insufficiency: Long-term ... diseases, check point
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
Pain - Diagnostic ... • Key point: If ... #Joint #Pain #MSK ... #rheumatology # ... #differential #diagnosis
Hyperparathyroidism - Primary vs Secondary vs Tertiary 
Lab Comparison:
 • Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,
Tertiary Lab Comparison ... urination, Abdominal pain ... weakness, Bone/joint ... pain Psychiatric ... Hyperparathyroidism #diagnosis