12 results
Multiple Myeloma Diagnosis and Management Summary
Clinical Signs:
 • hyperCalcemia 28% (bone demineralization)
 • Renal disease 48%
Multiple Myeloma ... Summary Clinical Signs ... hypercalcemia) • Anemia ... plasma clonal cell ... Diagnosis #Management #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
(Chronic Myeloid ... • Neutrophils (myeloid ... AML (Acute Myeloid ... - infiltrates (anemia ... Leukemia #Hematology #Oncology
Major neurocognitive disorders (MNCD): Diagnosis and workup 

1) Clinical diagnosis Cognitive impairment + loss of autonomy
2)
neurocognitive disorders (MNCD ... workup What type of MNCD ... - Progressive amnesia ... (parkinsonian signs ... Differential #Subtypes #Classification
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
incompetent • CLL ... CLL Epidemiology ... Physical Exam/Signs ... • Neutropenia, anemia ... diagnosis #workup #oncology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
Multiple Myeloma ... 40 ml/min A - Anemia ... marrow plasma cell ... diseases, CML, ... diagnosis #hematology #oncology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Management Summary myelo ... cytopenias (usually anemia ... Allogeneic stem cell ... treatment #hematology #oncology
Post-Transplantation Lymphoproliferative Disorders (PTLD)
Definition: Lymphoid and/or plasmacytic proliferations that occur as a result of immunosuppression in
hematopoietic cell ... Conditioning regimen Signs ... EBV viral load, signs ... Diagnosis and classification ... Lymphoproliferative #Disorders #oncology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
No evidence of anemia ... to IgM multiple myeloma ... insufficiency, Anemia ... to the plasma cell ... hematology #diagnosis #oncology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Lymphoma (HCV) • CLL ... POEMS (Sclerotic myeloma ... POEMS (Sclerotic myeloma ... (-) hemolytic anemia ... Differential #Diagnosis #Oncology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
count (anemia) ... three myeloid hematopoiesis ... • Aplastic Anemia ... Megaloblastic Anemia ... diagnosis #hematology #oncology