92 results
Myositis and Myopathies
#ESR #CK #Differential diagnosis of myopathy 
#Inflammatory #myopathies	#Dermatomyositis	
#muscle weakness
#Polymyositis	
#Inclusion body myositis
#Polymyalgia rheumatica	
#Fibromyalgia	
#Hypothyroid myopathy	
#Muscle stiffness
#Drug-induced
Differential diagnosis of myopathy ... muscle weakness #Polymyositis ... #Hypothyroid myopathy ... Statin-induced myopathy ... Cocaine-induced myopathy
Myositis and Myopathies
Polymyositis 
 • Progressive, symmetric muscle weakness 
 • Elevated CK, +Anti-Jo, +Anti-Mi2
Dermatomyositis
and Myopathies Polymyositis ... rimmed vacuoles HIV myopathy ... load Drug-induced myopathy ... Gemcitabine Lupus Myopathy ... 5-15% of lupus myopathy
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
• Inflammatory myopathy ... hypothyroid-induced myopathy ... erythematosus (SLE), polymyositis ... Statin-induced myopathy ... - Necrotizing myopathy
Creatine Kinase - Causes of Elevated CK Levels
Acute CK Elevation (Pain > Weakness):
 • RHABDOMYOLYSIS
Critical Illness Myopathy ... - Inflammatory myopathy ... dermatomyositis, polymyositis ... , necrotizing myopathy
Causes of Neuromuscular Weakness
 • Spinal Cord: Demyelinating Disease (MS), Epidural abscess, Infarction, Syringomyelia, Tetanus, Transverse
Mitochondrial myopathy ... Myotonic dystrophy, Polymyositis
Causes of Peripheral Weakness without Sensory Changes - Differential Diagnosis Algorithm
No Objective Weakness
 • Cardio-pulmonary disease
• Congenital Myopathy ... elevated CK • Polymyositis
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
proximal weakness Myopathy ... Inflammatory disorders: Polymyositis ... mediated necrotizing myopathy ... Dermatomyositis, polymyositis
Autoimmune Myositis - Differential Diagnosis Framework

Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
and lymphoma POLYMYOSITIS ... of the time) Polymyositis ... Misdiagnosed as: Polymyositis ... syndrome • If myopathy ... ANTI-MITOCHONDRIAL MYOPATHY
Causes of Proximal Muscle Weakness That May Mimic Inflammatory Myopathy
 • Central or peripheral neurologic disease
Mimic Inflammatory Myopathy ... Mitochondrial myopathy ... MuscleWeakness #Myopathy
Idiopathic Inflammatory Myopathies - 
Dermatomyositis (DM), Immune-Mediated Necrotizing Myopathy (IMNM), Antisynthetase Syndrome (ASS), Inclusion Body Myositis
Immune-Mediated Necrotizing Myopathy ... Myopathies #Idiopathic #Myopathy