329 results
Coagulation cascade and anticoagulants 

Satyendra Dhar MD, @DharSaty

#coagulation #coumadin #heparin #warfarin #apaxiban #pradaxa #xarelto #DOAC #vWF
coagulation #coumadin #heparin ... warfarin #apaxiban #pradaxa ... #xarelto #DOAC
Anticoagulant specific factor inhibition. 

#anticoagulation #clotting #INR #heparin #LMWH #NOAC #warfarin #coumadin #rivaroxaban  #Xarelto #apixaban
clotting #INR #heparin ... #rivaroxaban #Xarelto ... #dabigatran #Pradaxa
Anticoagulants Common Reversal Agents
 - Warfarin (Coumadin) → Vitamin K (Phytonadione), 4-factor PCC (Kcentra)
 - Heparin/LMWH
PCC (Kcentra) - Heparin ... - Dabigatran (Pradaxa ... , Rivaroxaban (Xarelto
Dabigatran Etexilate - direct acting thrombin inhibitor used in DVT/PE prophylaxis. Reversal agent: idarucizumab.

#Pharmacology #Dabigatran #Pradaxa
Pharmacology #Dabigatran #Pradaxa
Heparin, Fondaparinux, and Novel Oral Anticoagulants - Pathophysiology

Anticoagulation with parenteral (intravenous or subcutaneous) and oral anticoagulants
Heparin, Fondaparinux ... parenteral agents (e.g. heparin ... Unfractionated heparin ... molecular weight heparin ... smaller average heparin
Xarelto® proper use based upon dosing
20 mg daily: take with evening meal
15 mg daily: take with
Xarelto® proper ... without food #Xarelto
Indications for Emergent Hemodialysis

Indications: "AEIOU" 
 A - Acidosis ( pH < 7.1 ) 
 E
- Dabigatran (Pradaxa
Heparin and Low Molecular Weight Heparin (LMWH)–Mediated Inactivation of Thrombin or Factor Xa 
 - Interaction
Heparin and Low ... Molecular Weight Heparin ... antithrombin with heparin ... Unfractionated heparin ... factor Xa #Heparin
Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage

The table summarizes the recommendations for adult patients on
molecular weight heparins ... Unfractionated heparin
Heparin Induced Thrombocytopenia (HIT) - Likelihood, Diagnosis and Management
 - HIT Suspected
 - Calculate 4T Score
Heparin Induced ... - Start/Stop Heparin ... Results #HIT #Heparin