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diagnosis rheumatology dermatology classification neurology behcet cns cryoglobulins cutaneous dermatologic dermpath erythematosus gpa granulomatosis lesions lupus manifestations myelitis nonpalpable palpable
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
Identification of causes ... Connective tissue disease ... (10%) : SLE +++ ... #semiology #signs ... lesions #diagnosis #clinical
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Splenomegaly - CTD (SLE ... Kasabach-Merritt syndrome ... /HSP • Cryoglobulinemia ... Associated - SLE
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... Syndrome: • Clinical ... • Autoimmune diseases ... : - 10% SLE or
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
) Clinical Manifestations ... Demyelinating Syndrome ... Cerebrovascular Disease ... autoantibodies that will cause ... #management #treatment
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential ... tract, and often causes ... purpura: strong sign ... , and SLE) • Urinalysis ... #rheumatology #
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Rarely dominate the clinical ... reticularis Differential ... purpura • Mixed cryoglobulinemia ... • Goodpasture syndrome
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
(Clinical Dx). ... ) Differential Diagnosis ... Oral aphthae : SLE ... #diagnosis #management ... #signs #symptoms
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... , such as SLE, atherosclerotic ... purpura: Strong sign ... tract, and often causes ... / ANCA + MPO) Cryoglobulinemic
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Hypocomplementemia • Can cause ... salivary ducts Clinical ... : • 7%, Cryoglobulinemia ... Diagnosis #Management
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
Transverse Myelitis - Clinical ... • Bilateral signs ... • Infectious causes ... - Sjogren - Vasculitis ... #neurology #differential
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