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diagnosis causes differential abnormal aptt management prolonged pt acute arterial chronic cirrhosis dic embolism failure hepatology intravascular pathophysiology thrombosis vascular
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Clinical Guidelines ... months without treatment ... Kidney Failure Coagulation ... Hepatitis (AAH) Drug-Induced ... #gastroenterology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... organ damage Clinical ... DIC • Severe Liver ... + Bleeding Treatment ... #management #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early liver disease ... Reduced liver synthesis ... Disseminated intravascular ... #differential #hematology ... #coagulation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
deficiency • Reduced ... liver synthesis ... hemorrhage • Disseminated ... #differential #hematology ... #coagulation
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Syndrome, Ischemic Liver ... Hyperhomocysteinemia - Heparin-induced ... thrombocytopenia - Disseminated ... intravascular coagulation ... pathophysiology #hematology
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