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differential causes dermatology generalized leukemia management mds myelodysplastic pruritus secondary systemic workup cell cll lymphocytic myelodysplasia plasmacytoma platelets primary thrombocytosis
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... dys- (abnormal) -plastic ... cytopenias (usually anemia ... Myelodysplastic #Syndrome ... #hematology #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... Constitutional Syndromes ... anemia Treatment ... #Anemia #oncology ... #hematology #diagnosis
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
hemolysis, deficiency anemia ... Metastatic cancer, Lymphoma ... Kawasaki, Nephrotic syndrome ... • Infections: Chronic ... #Algorithm #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
• Neutropenia, anemia ... • Richter’s Syndrome ... leukemia • Sezary syndrome ... #workup #oncology ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
correlates with prognosis ... • Aplastic Anemia ... Marrow Failure • Chronic ... #diagnosis #hematology ... #oncology
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Algorithm - Systemic ... Creatinine & BUN: • Chronic ... renal failure/uremia ... Differential: • Lymphoma ... Myelodisplastic syndrome
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Algorithm Blood ... Creatinine & BUN: • Chronic ... renal failure/uremia ... Differential: • Lymphoma ... Myelodisplastic syndrome
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
• No CRAB - no anemia ... Bone marrow Treatment ... as required Prognosis ... #Plasmacytoma #Oncology ... #Hematology
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