13 results
diagnosis hematology algorithm pancytopenia causes deficiency hemolytic management oncology workup agglutinin classification cold common cvid disease erythematosus extravascular folate folicacid
Pancytopenia - Differential Diagnosis Congenital Diseases: • GATA2 deficiency • Fanconi’s anemia • Wiskott-Aldrich syndrome • Ribosomopathy or telomeropathy Cancer: • Leukemia • Lymphoma Inflammatory
deficiency • Fanconi’s anemia ... telomeropathy Cancer ... Inflammatory and ... Antibody-mediated hemolysis ... Nutritional
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
anemia): ... lymphoproliferative disorders ... disease, Copper and ... Extravascular #Causes #differential ... #anemia
Causes of Iron Deficiency • Diet: ↓ Intake, e.g. vegan, Malnutrition, Polyphenol / tannins, ↓ Vitamin
: Gl lesions / cancer ... hepcidin) • Others: Hemolysis ... Iron metabolism disorders ... #diagnosis #anemia ... #nutrition
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Differential Diagnosis ... Algorithm Consumption Disorders ... Drugs Nutritional ... Eating disorders ... Acquired Aplastic Anemia
Pancytopenia - Workup and Differential Diagnosis Algorithm Consumption Disorders 1. Autoimmune Mediated Pancytopenia 2. Splenic Sequestration Peripheral Destruction
Differential Diagnosis ... Algorithm Consumption Disorders ... Drugs Nutritional ... Eating disorders ... Acquired Aplastic Anemia
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
blood loss, Acute hemolysis ... , deficiency anemia ... Malignancy: Metastatic cancer ... Inflammatory Conditions: Rheumatologic ... Acute bacterial and
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
lymphoproliferative disorder ... • Symptoms of anemia ... anemia • Cold ... younger pts) Differential ... #anemia #hematology
Etiologies of Folate Deficiency • Decreased dietary intake - uncommon in this era • Increased requirements
pregnant have hemolytic ... anemia, or psoriasis ... deficiency #FolicAcid #differential ... #diagnosis #hematology ... #nutrition
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... Lymphoma or other cancers ... breast cancer ... autoimmune hemolytic ... anemia) • Systemic
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... Weight loss • Anemia ... nodosum • Immune hemolytic ... anemia • Pain ... Immunohistochemical studies (to differentiate
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