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diagnosis pathophysiology syndrome 21hydroxylasedeficiency 21ohd bulimianervosa caudaequina cushings diabetes diabeticketoacidosis differential dka erythematosus genetics glftap hypercortisolism hyperthyroidism lupus macroadenoma management
Systemic Lupus Erythematosus (SLE): Musculoskeletal Manifestations • Immune Complex Deposition - Arthralgia, Arthritis
Myopathy (Also caused ... Erythematosus #SLE #MSK ... Musculoskeletal #Complications ... pathophysiology #signs ... #symptoms #diagnosis
Cauda Equina Syndrome Causes: • Large lumbar degenerative disc herniation (central) • Severe lumbar spondylosis • Neoplasm
Equina Syndrome Causes ... lumbar spine Signs ... / Symptoms / Complications ... CaudaEquina #Syndrome #MSK ... #signs
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
out of cells may cause ... To prevent hypokalemia ... Signs/Symptoms/Complications ... Abdominal pain, nausea ... pathophysiology #endocrinology
21-Hydroxylase Deficiency (21-OHD): Pathogenesis and Clinical Findings Autosomal recessive mutation in CYP21A2 coding for the enzyme 21-OHase
enzyme 21-OHase causes ... Signs/Symptoms/Complications ... pathophysiology #genetics #endocrinology
Pituitary Mass Effects - Pathogenesis and Clinical Findings • Pituitary turnors are almost always a benign
For pituitary masses ... Signs / Symptoms ... / Complications ... Headaches • Nausea ... #SideEffects #endocrinology
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
hyperphosphatemia, hypercalcemia ... are not caused ... anterior/posterior MSK ... Diagnosis #Management #Signs ... #Symptoms
Hyperthyroidism Overview Clinical Manifestation of Hyperthyroidism: • Fatigue • Weight loss • Heat intolerance • Depression, nervousness
↑ T3 - Mild hypercalcemia ... hyperthyroidism #causes ... #differential #endocrinology ... #signs #symptoms
Cushing's Syndrome - Hypercortisolism - Diagnosis and Clinical Features 1) Skin • Thin, easily bruisable skin with
, oral cavity) Caused ... polyuria in the case ... Cataracts Labs: Hypokalemia ... Hypercortisolism #Diagnosis #signs ... #symptoms #endocrinology
Paget’s Disease: Complications Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation MSK
Paget’s Disease: Complications ... Abnormal Osteoclasts cause ... bone formation MSK ... pathophysiology #diagnosis #signs ... #symptoms #complications
Bulimia Nervosa: Complications GASTROINTESTINAL • Dehydration & inability to digest food -> Constipation • Recurrent vomiting exposes
Bulimia Nervosa: Complications ... hormone levels cause ... ) • Overall: hypokalemia ... pathophysiology #diagnosis #signs ... #symptoms #psychiatry
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