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diagnosis liver transaminitis chemistry cholestatic drug function gastroenterology hepatitis hepatocellular idiosyncratic induced interpretation management rvalue tests
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Liver Enzymes (LFTs ... more specific for hepatic ... #LFTs #Hepatocellular ... Transaminitis #diagnosis #differential ... #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
) - Differential ... (>1000): • DILI ... Drug-induced liver injury ... liver) • Non-hepatic ... Diagnosis #hepatology
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
dose dependent injury ... Chronic - ongoing ↑ LFTs ... Idiosyncratic #differential ... gastroenterology #algorithm ... gastroenterology #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Diagnosis Algorithm ... : • Hepatic vein ... Source of Liver Enzyme ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... replaced by non-hepatic ... Source of Liver Enzyme ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
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