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liver transaminitis algorithm chemistry classification drug embolism function gastroenterology idiosyncratic induced interpretation management pathophysiology rheumatology rvalue tests thrombosis vascular vasculitides
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Chronic - ongoing ↑ LFTs ... Idiosyncratic #differential ... #Diagnosis #Management ... gastroenterology #hepatology
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Function Tests (LFTs ... ) - Differential ... (>1000): • DILI ... Drug-induced liver injury ... Diagnosis #hepatology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Thrombosis - Differential ... Diagnosis Framework ... Vasculitis • Injury ... pathophysiology #hematology ... #differential #
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... liver #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis ... #LFTs #RValue #
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
syndrome - Coronary arteries ... Thrombosis and arterial ... diminished, or tender pulses ... Tests: • CBC • LFT ... #diagnosis #rheumatology
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