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diagnosis rheumatology erythematosus signs sle symptoms systemic agglutinin arterial arteritis classification cold dermatology disease embolism gca giantcell hemolytic management nonpalpable
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Features of Systemic Lupus ... Butterfly rash, Vasculitis ... Cranial nerve lesions ... Endocarditis, Aortic ... ) Blood (75%): Anemia
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential ... ischemic skin lesions ... such as systemic lupus ... diminished, or tender pulses ... #rheumatology #
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... hemorrhagic skin lesions ... - Hemolytic anemia ... Vasculopathy #Purpura #Differential ... #Diagnosis #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Autoimmunity: • -MM/WM: Vasculitis ... (-) hemolytic anemia ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... • Symptoms of anemia ... • hemolytic anemia ... younger pts) Differential ... #hematology #diagnosis
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Arterial Thrombosis - Differential ... atherosclerotic lesions ... 19 - PNH - Vasculitis ... pathophysiology #hematology ... #differential #
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... diminished, or tender pulses ... < 30 years • Aorta ... claudication, pulse ... Arteritis): • Aorta
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
papulosquamous lesions ... permanent alopecia Differential ... ANCA-associated vasculitis ... • Mesenteric vasculitis ... lymphopenia, low PLT • Anemia
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
systemic inflammatory vasculitis ... those coming off aorta ... very remarkable w/differential ... systemic complaints- anemia ... required due to skip lesions
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