9 results
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Rarely dominate the clinical ... , Palpable purpura ... • Palpable purpura ... Vesicles overlying purpuric ... Henoch-Schönlein purpura
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
- Differential Diagnosis ... Small Vessel: Petechiae ... , Palpable purpura ... Vasculitis: - Ig A (HSP ... Disease • Cogan syndrome
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis: • Purpura ... purpura: Strong ... purpura • Pauci ... purpura, joint ... purpura (lower
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Clinical Features ... rash, Vasculitis, Purpura ... Demyelinating syndromes ... erythematosus #signs ... #symptoms #diagnosis
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
multiforme-like lesions, palpable ... purpura, Pathergy ... (Clinical Dx). ... #diagnosis #management ... #signs #symptoms
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
organ damage Clinical ... • Purpura • ... Palpable variants ... Hemorrhagic bullae • Purpura ... #Coagulation #diagnosis
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
easy bruising to purpura ... mucosal bleeding (Petechial ... or purpuric rash ... 5000 to 10,000 ng/mL ... #Diagnosis #Management
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings

 - Infectious Agents - 50% have
Henoch Scholein Purpura ... Pathogenesis and Clinical ... and ankles) #HSP ... Pathophysiology #Diagnosis ... #Signs #Symptoms
Strongyloides Stercoralis
EPIDEMIOLOGY - ASSOCIATED WITH SOUTHEASTERN U.S.:
 • 0-6% US Prevalence of those:
 • ~30% Asymptomatic
contact, farming CLINICAL ... HYPERINFECTION SYNDROME ... distension, fever, petechia ... /purpura, cough, ... #management #parasites