8 results
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Rarely dominate the clinical ... , Palpable purpura ... • Palpable purpura ... Vesicles overlying purpuric ... Henoch-Schönlein purpura
Non-HCV infectious mixed cryoglobulinemia vasculitis - Diagnosis, causes and management - French Vasculitis Study Group

< 5%
Diagnosis, causes and management ... vasculitis Clinical ... manifestations - Skin ... involvement with purpura ... #Diagnosis #Management
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
Involving the Skin ... Vasculitis Skin ... Small Vessel: Petechiae ... , Palpable purpura ... Urticarial/LCV) - Cryoglobulinemic
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Arthralgia - Purpura ... Syndrome: • Clinical ... triad of Palpable ... purpura, Arthralgia ... Henoch-Schönlein purpura
Scurvy (Vitamin C Deficiency) - Diagnosis and Management

Vitamin C is required for hydroxylation of proline residues
Diagnosis and Management ... poor nutrition Clinical ... Purpura • Perifollicular ... • Petechiae, purpura ... Henoch-Schonlein purpura
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
protein C and S Pathophysiology ... organ damage Clinical ... • Purpura • ... Palpable variants ... Hemorrhagic bullae • Purpura
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
easy bruising to purpura ... mucosal bleeding (Petechial ... or purpuric rash ... 5000 to 10,000 ng/mL ... Syndrome #Diagnosis #Management
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
association • M > F Clinical ... multiforme-like lesions, palpable ... purpura, Pathergy ... Behcet syndrome (Clinical ... Syndrome #diagnosis #management