21 results
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... PURPURA: Platelet ... Acute Infectious Purpura ... OF PALPABLE PURPURA ... Ig A vasculitis/HSP
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... purpura (16%) ... purpura • Vesicles ... overlying purpuric ... Henoch-Schönlein purpura
Diagnosis of IgA Vasculitis (Henoch-Schönlein Purpura) - French Vasculitis Study Group 

1) Suggestive clinical manifestations
Henoch-Schönlein Purpura ... - Symmetric palpable ... purpura mainly ... #Diagnosis #Rheumatology ... #Peds #Pediatrics
Pediatric Causes of Abdominal Pain

Surgical:
 - Acute appendicitis 
 - Intestinal obstruction including intussusception 
 -
Pediatric Causes ... Henoch—Schönlein purpura ... the testis - Hip ... #Causes #Differential ... #Diagnosis #Peds
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
- Differential Diagnosis ... Vessel: Petechiae, Palpable ... purpura, Hemorrhagic ... Vasculitis: - Ig A (HSP ... #dermatology #rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis: • Purpura ... purpura: Strong ... purpura • Pauci ... purpura, joint ... purpura (lower
Polyarteritis Nodosa (PAN): Pathogenesis and Clinical Findings

Medical Comorbidities Malignancies (most commonly hairy-cell leukemia)
Immunogenetic Predisposition: patient is
Pathogenesis and Clinical ... Viral replication causes ... endothelial cells - Palpable ... or necrotic purpura ... #Diagnosis #Signs
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
three primary pathophysiologic ... causes differentiated ... Henoch-SchonIein Purpura ... #differential #diagnosis ... #algorithm #rheumatology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
organ damage Clinical ... Petechiae • Purpura ... • Palpable variants ... Hemorrhagic bullae • Purpura ... #Coagulation #diagnosis
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
Arthralgia - Purpura ... Syndrome: • Clinical ... triad of Palpable ... purpura, Arthralgia ... Henoch-Schönlein purpura