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diagnosis differential algorithm hepatology management clinical cholangitis cirrhosis dermatology infections infectiousdiseases pbc pruritus workup abdominal acute ascites bronchiectasis cardiology cbd
Causes of Severe Acute Liver Injury - Ichemic hepatitis - Acute biliary obstruction - Drug-Induced liver
Causes of Severe ... hepatitis - Acute biliary ... Hemochromatosis - Primary ... biliary cholangitis ... Severe #Acute #Causes
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... ducts causes cholestasis ... No extrahepatic biliary ... malignancy #Primary ... #Biliary #Cirrhosis
Primary Biliary Cirrhosis - Pathophysiology Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish Epigentics Risk
Primary Biliary ... gradual loss of bile ... inflammation and biliary ... Cholestasis #PBC #Primary ... #Biliary #Cirrhosis
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
genes coding for bile ... cholestasis, and some cases ... miscellaneous causes ... external pressure on bile ... #differential #causes
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
Intestine - Other causes ... - Drugs - Primary ... biliary Cholangitis ... PSC - Other biliary ... diseases/Bile duct
Hepatomegaly - Differential Diagnosis Algorithm Malignant • Primary Carcinoma • Metastases • Lymphoma • Leukemia • Polycythemia
Malignant • Primary ... Histiocytosis X • Primary ... Cholangitis • Primary ... Biliary Cirrhosis ... Diagnosis #Algorithm #Causes
Jaundice - Differential Diagnosis Algorithm Pre-Hepatic - Unconjugated Hyperbilirubinemia Increased Production • Hemolysis • Ineffective Erythropoiesis • Hematoma Decreased
on Ultrasound Biliary ... Gallstones • Biliary ... Cholangiocarcinoma • Primary ... Diagnosis #Algorithm #Causes
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
disease US — Normal Bile ... US - Dilated Bile ... Ducts • Common Bile ... Duct Stone • Biliary ... Diagnosis #Algorithm #Causes
Rapidly Growing Mycobacterial Infections • Mycobacterium abscessus - Is the most pathogenic and the most likely
most likely to cause ... Primarily in patients ... Primary skin and ... Rarely, other site ... It can also cause
Causes of Ascites - Differential Diagnosis Algorithm Portal Hypertension - Prehepatic: • Portal vein thrombosis • Splenic
Causes of Ascites ... liver failure • Primary ... biliary cholangitis ... • Primary sclerosing ... Algorithm #Hepatology #causes
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