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Pseudogout: pathogenesis and clinical findings - Idiopathic (vast majority of cases) -> Mechanism unknown - Familial
vast majority of cases ... ANKH gene, Incr pyrophosphate ... dihydrate (CPPD ... and/or x-ray - CPPD ... Chondrocalcinosis #Pseudogout #CPPD
CPPD vs Gout == CPPD == Think About CPPD When: • Self-limited synovitis after surgery/trauma (> 65
CPPD vs Gout ... == CPPD == Think ... About CPPD When ... Pathophysiology: • Pyrophosphate ... Asymptomatic CPPD
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD) Pathophysiology: Pyrophosphate produced by chondrocytes likely precipitates with calcium to
Summary - Calcium Pyrophosphate ... Pathophysiology: Pyrophosphate ... calcium to form CPP ... Chronic calcium pyrophosphate ... #Calcium #Pyrophosphate
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
Most cases diagnosed ... nephrocalcinosis • CPPD ... • Inorganic pyrophosphate ... PPi (inorganic pyrophosphate ... Phosphatase: • Other causes
Pathogens in Pneumonia Here is a quick review of the pathogens causing pneumonia (useful for enumerating differentials
your grand rounds/cases ... H. influenzae (COPD ... Pseudomonas — COPD ... Legionella spp (COPD ... #Microbiology #Causes
Causes of Chronic Dyspnea - Differential Diagnosis Algorithm Pericardial • Effusion • Cardiac Tamponade* • Constriction Myocardial •
Causes of Chronic ... • Asthma • COPD ... Pleural Thickening/Masses ... Pneumonia • ARDS • COPD ... Diagnosis #Algorithm #Causes
Tachypnea - Differential Diagnosis Framework Definitions • Tachypnea: Respiratory rate > 20/min, shallow breathing in adults •
breathing Pulmonary Causes ... • Asthma • COPD ... PVFM) Cardiac Causes ... Hematologic Causes ... acidosis of any cause
Sebaceous hyperplasia - Yellow papule - Donut-shape - Central umbilication - Telangiectasia
Usually multiple - Causes ... Benign #Clinical #Photo
Dyspnea - Differential Diagnosis Framework Cardiovascular Causes of Dyspnea: • Myocardium: - Heart failure - CAD/ACS - Valvulopathy • Electrical: -
Cardiovascular Causes ... Tamponade Pulmonary Causes ... - Asthma - COPD ... syndrome Other Causes ... differential #diagnosis #causes
Hypoxemic Respiratory Failure - Differential Diagnosis Framework DECREASED INSPIRED OXYGEN • Low PATM Can decrease first part
average settings • Causes ... gas equation • Causes ... • Most common cause ... to hypoxemia • Causes ... Pneumonia, asthma, COPD
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