54 results
Pseudogout: pathogenesis and clinical findings
 - Idiopathic (vast majority of cases) -> Mechanism unknown
 - Familial
ANKH gene, Incr pyrophosphate ... dihydrate (CPPD ... activity, reduces pyrophosphate ... and/or x-ray - CPPD ... Chondrocalcinosis #Pseudogout #CPPD
First-line therapies for Asthma, Asthma-COPD Overlap and COPD

The diagnosis of COPD, asthma, and ACO initially requires
Asthma, Asthma-COPD ... Overlap and COPD ... The diagnosis of COPD ... summary of the differential ... ACO = asthma-COPD
Pathogens in Pneumonia

Here is a quick review of the pathogens causing pneumonia (useful for enumerating differentials
H. influenzae (COPD ... Moraxella catarrhalis (COPD ... Pseudomonas — COPD ... Legionella spp (COPD ... Chlamydia pneumoniae (COPD
Pseudogout Summary - Calcium Pyrophosphate Deposition Disease (CPPD)

Pathophysiology:
Pyrophosphate produced by chondrocytes likely precipitates with calcium to
Deposition Disease (CPPD ... Think About CPPD ... Asymptomatic CPPD ... monoarticular CPPD ... #Pseudogout #CPPD
CPPD vs Gout

== CPPD == 

Think About CPPD When:
 • Self-limited synovitis after surgery/trauma (> 65
CPPD vs Gout ... == CPPD == Think ... About CPPD When ... Pathophysiology: • Pyrophosphate ... Asymptomatic CPPD
Causes of Chronic Dyspnea - Differential Diagnosis Algorithm
Pericardial
 • Effusion
 • Cardiac Tamponade*
 • Constriction
Myocardial
 •
Chronic Dyspnea - Differential ... Artery Disease • Stable ... • Asthma • COPD ... Pneumonia • ARDS • COPD ... #Dyspnea #SOB #Differential
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Anemia (AIHA) - Differential ... Diagnosis Table ... AIHA (48-70%) Cold ... #Anemia #AIHA #Differential ... #Diagnosis #Table
Acute Hypoxemia - Differential Diagnosis
 • Hyperacute: Aspiration, Flash Pulmonary Edema, Mucous Plugging, Bronchospasm, Pulmonary Embolism,
Acute Hypoxemia - Differential ... pHTN, Advanced COPD ... Disease: Asthma, COPD ... Hypoxemia #hypoxia #Differential
Daliresp (Roflumilast) 
Indication: Reduce risk of COPD exacerbations 
Drug Class: Selective Phosphodiesterase-4 (PDE4) Inhibitor 
GOLD 2019
Reduce risk of COPD ... Initiate if severe COPD ... Dosing: 250 mcg tablet ... the treatment of COPD ... #Pharmacology #COPD
Hyponatremia - Differential Diagnosis by Mechanism
Decr Blood Pressure (“Decr Effective Circulating Volume”) 
 - Volume depletion
Hyponatremia - Differential ... e.g. pneumonia, COPD ... #Hyponatremia #Differential ... #Diagnosis #Table