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Stiff Person Syndrome (SPS) - Diagnosis and Management Summary Epidemiology: • Prevalence: 1-2 cases per million -
Stiff Person Syndrome ... Diagnosis and Management ... an autoimmune response ... positive therapeutic response ... SPS #Diagnosis #Management
Systemic Inflammatory Response Syndrome (SIRS) • Non-specific (infections vs non-infectious) • ≥2 of the following: o Temp >38°C or <36°C o HR >90 bpm o RR
Systemic Inflammatory Response ... Syndrome (SIRS) ... dysregulated host response ... >2 mmol/L Management
Guillain-Barre Syndrome - Summary Acute AIDP that presents with rapidly progressive flaccid weakness Epidemiology: • 1-2 cases/100,000 per
Guillain-Barre Syndrome ... Pathophysiology: • Immune response ... Miller Fisher Syndrome ... Guillain #Barre #Syndrome ... #diagnosis #management
Anti-IL6 Agents (Tocilizumab, Siltuximab) in COVID19 IL-6 activates T cells and macrophages, among other cell types (see
Cytokine Activation Syndrome ... if inadequate response ... #Pharmacology #Management
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Behçet's Syndrome ... Pathergy (an inflamed response ... tests in Behcet syndrome ... adenopathy (PFAPA) syndrome ... #diagnosis #management
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... blast cells → SIRS response ... Differentiation #Syndrome ... APML #diagnosis #management
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
SAPHO Syndrome Summary ... SAPHO syndrome is ... blockers had the best response ... #SAPHO #Syndrome ... Rheumatology #diagnosis #management
Guillain-Barré Syndrome (GBS) Acute autoimmune demyelinating polyradiculoneuropathy that presents with rapidly progressive flaccid weakness Epidemiology: • Incidence: 1
Guillain-Barré Syndrome ... Pathogenesis: • Immune response ... • Immune response ... Guillain #Barre #Syndrome ... #diagnosis #management
Syncope is a sudden, transient loss of consciousness, which is thought to be secondary to cerebral
due to vasovagal responses ... carotid sinus syndrome ... further guide management
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Overwhelming clinical syndrome ... If no response HLH ... Lymphohistiocytosis #diagnosis #management
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