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diagnosis symptoms signs management differential cardiology nephrology endocrinology pharmacology syndrome hematology infectiousdiseases algorithm msk causes complications lifecycle ophthalmology treatment cdc
Complement Pathways - Classical Pathway - Lectin Pathway - Alternative Pathway #Complement #Pathway #hematology #pathophysiology
Complement Pathways ... Alternative Pathway #Complement ... Pathway #hematology #pathophysiology
Overview of the Complement System - Classical and Alternative Pathways by Dr.Grace Leo @gracie_leo #Complement #System #Classical #Alternative
Overview of the Complement ... gracie_leo #Complement ... Alternative #Pathways #Pathophysiology
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Hypocomplementemia - CHAMPS ... Hypocomplementemia #Low #Complement ... #CHAMPS #Mnemonic
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... Complex Formation - Complement ... Vasculitis #HUV #Pathophysiology
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
dead tissue • Complement ... activation of complement ... #Inflammation #pathophysiology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
three primary pathophysiologic ... staining): • Low Complement ... Idiopathic • Normal Complement
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
is rare Normal complement ... response: The complement ... activation -> Complement ... C7, C8, C9 -> Complement ... #pathophysiology
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
staining (lg + complement ... monoclonal gammopathy Complement-Mediated ... MGPN • Complement ... of alternative complement ... MPGN without complement
Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
activation • Complement ... tagged with C3 complement ... - Activate Complement ... : Abs activate complement ... Humoral #Immunity #pathophysiology
Systemic Lupus Erythematosus (SLE): Pathogenesis • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
HLA-DR3 genes, complement ... self-antigens, activating complement ... Erythematosus #SLE #Pathophysiology
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