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Intrinsic Renal Disease - Differential Diagnosis Vascular: • Macrovascular: Renal artery occlusion, Fibromuscular disease • Microvascular: TTP/HUS,
, Amyloidosis, MPGN ... • Nephritic: RPGN ... , IgA, Alport, MPGN
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Glomerulonephritis (RPGN ... ) RPGN has three ... pathophysiologic causes ... StanfordChiefs #RPGN
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm Reactive: - Systemic Inflammatory •
Causes of Diffuse ... Neoplastic: - Leukemia ... Lymphoblastic Leukemia ... Chronic Lymphocytic Leukemia ... Diagnosis #Algorithm #Causes
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Leukemias Overview ... , CLL Acute leukemias ... Chronic leukemia ... Lymphoblastic Leukemia ... -> AML: Blast crises
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic Leukemia ... • Most common leukemia ... - Leukemia cutis ... • MPGN: Paraneoplastic ... to DLBCL, PML leukemia
Causes of Neutrophilia - Increased Neutrophils - Differential Diagnosis Algorithm Infection • Bacterial • Abscess • Viral Medications
Causes of Neutrophilia ... Chronic myelogenous leukemia ... Polycythemia vera Acute Leukemia ... Diagnosis #Algorithm #Causes
Causes of Diffuse and Localized Lymphadenopathy - Differential Diagnosis Algorithm • Reactive (Inflammatory / Infectious) •
Causes of Diffuse ... • Neoplastic (Leukemia ... Diagnosis #Algorithm #Causes
Hyperviscosity Syndrome - Causes and Treatment - Waldenstrom macroglobulinemia (most common) / Plasmapheresis - Multiple
Hyperviscosity Syndrome - Causes ... Plasmapheresis - Leukemia ... Hydroxyurea - Leukemia ... Hyperviscosity #Syndrome #Causes
Basophilia - Differential Diagnosis Framework Basophils < 1% of the total white blood cell count Basophils function similarly
Chronic myeloid leukemia ... Acute myeloid leukemia ... Acute basophilic leukemia ... Chickenpox Other Causes ... Differential #Diagnosis #causes
Acute promyelocytic leukemia (blood). Typical morphologic features are bilobed ("butterfly") nuclei with dispersed chromatin, subtle to
promyelocytic leukemia ... features in most cases ... promyelocytic #leukemia
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