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management hematology liver algorithm blood reactions aclf acute aflp aih alcoholic anemia aplastic autoimmune chronic cirrhosis dili druginduced failure fatty
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
months without treatment ... Drug-Induced Liver Injury ... (DILI) Viral Hepatitis ... #Cirrhosis #Hepatology ... gastroenterology #management #diagnosis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
DILI) - Stepwise Diagnosis ... non-essential drug/HDS treatments ... for alternative causes ... #Diagnosis #Algorithm ... #hepatology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
acid metabolism products ... = nonspecific (nausea ... ) Differential Diagnosis ... : Viral Hepatitis ... Liver #Pregnancy #hepatology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
Autoimmune Hepatitis ... to acute liver failure ... pattern of liver injury ... regarding need for treatment ... #Management #Hepatology
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
hypoTN, renal failure ... Causes purpura & ... Related Acute Lung Injury ... #Transfusions #diagnosis ... #management #hematology
Syphilis - Clinical Manifestations and Treatment 1) Primary Syphilis • Direct lesion contact during sex is responsible
responsible for most cases ... → Ulcerates to produce ... and acute renal failure ... Gastrointestinal: Syphilitic hepatitis ... Syphilis #stages #diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Marrow (Toxic injury ... and petechiae Causes ... Aplastic Anemia: - Hepatitis ... aplastic anemia Treatment ... #diagnosis #management
Alcoholic Hepatitis - Management Algorithm Assess Eligibility for Treatment: - Maddrey Discriminant Function ≥ (or possibly MELD
Alcoholic Hepatitis ... exclude other causes ... - Acute kidney injury ... - Multiorgan failure ... Management #Algorithm #hepatology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
hypoTN, renal failure ... Causes purpura & ... Related Acute Lung Injury ... #Transfusion #diagnosis ... #management #hematology
Hepatorenal Syndrome (HRS) Definition: • Functional, potentially reversible kidney impairment. • Occurs in advanced liver disease: cirrhosis, severe alcoholic
severe alcoholic hepatitis ... or acute liver failure ... • Caused by splanchnic ... Treatment Overview ... Hepatorenal #Syndrome #Hepatology
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