9 results
Volume Based Approach to Hyponatremia
Hypovolemic, Serum uric acid >4
 • Urine Na <20: Extra-renal losses
 •
uric acid >4 • Urine ... Cirrhosis, Nephrotic syndrome ... • Urine Na > 30 ... Hyponatremia #algorithm #diagnosis ... #sodium #low #nephrology
Inherited Defects in Kidney Tubule Epithelial Cells

Renal glucosuria - Na+-dependent glucose cotransporter
Cystinuria - Amino acid transporter
Bartter
transporter Bartter syndrome ... limb Gitelman syndrome ... tubule Liddle syndrome ... deficiency Nephrogenic syndrome ... #Table
Hypernatremia - Differential Diagnosis Workup Algorithm

1) Check Urine Osmolality:
 > 600 mOsm/kg - Implies extrarenal mechanism
- Differential Diagnosis ... Algorithm 1) Check Urine ... Hypervolemic: Conn syndrome ... , Cushing syndrome ... #sodium
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
diuretic use, Bartter syndrome ... , Gitelman syndrome ... sodium is typically ... the excretion of sodium ... #differential #diagnosis
Physiologic Approach to Hypotonic Hyponatremia
The next time you have a case of hypotonic hyponatremia, give the
volume-based algorithm Urine ... Cirrhosis, Nephrotic syndrome ... #differential #diagnosis ... #table #sodium ... #nephrology
Causes of Secondary Hypertension - Differential Diagnosis and Screening Testing
Common causes: 
 • Renal parenchymal disease
Oral sodium loading ... test (with 24-h urine ... • Cushing’s syndrome ... Mineralocorticoid excess syndromes ... Screening #Workup #table
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary

Causes of Rhabdomyolysis:
 • Trauma:
	- Immobilization
	- Crush injury
	- Compartment
- Differential Diagnosis ... - Compartment syndrome ... Neuroleptic malignant syndrome ... Weakness - Dark urine ... or compartment syndrome
Hyponatremia - Diagnosis and Treatment
Hyponatremia is usually caused by the inability to excrete water normally.
Hyponatremia - Diagnosis ... Measure urine osmolality ... demyelination syndrome ... #Differential #Diagnosis ... #sodium
Gitelman Syndrome Overview

What?
• Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter
• Gitelman's syndrome
Gitelman Syndrome ... • Gitelman's syndrome ... Hypocalciuria (spot urine ... • Bartter syndrome ... #diagnosis #nephrology