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symptoms dermatomyositis rheumatology allergy anaphylaxis antimda5 antimda5dm antinxp2 antinxp2dm biliary cholangitis cirrhosis complications differential extraarticular heat heatstroke hepatology illness lupus
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
Mucocutaneous Manifestations ... hair follicles -> causes ... inflammation on skin ... #pathophysiology ... #diagnosis #signs
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
Extra-articular manifestations ... inflammation tends to cause ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms ... #diagnosis #ExtraArticular
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
DERMATOMYOSITIS Cutaneous manifestations ... chest (in a V-sign ... anti-NXP2 Abs Lung Manifestations ... #rheumatology #dermatology ... #diagnosis
Manifestations of Anaphylaxis by Body System Dermatologic/mucosal - Eyes: periorbital swelling/erythema, injected conjunctiva, tears - Oral mucosa:
Manifestations of ... Body System Dermatologic ... tongue and lips - Skin ... cessation of play #Diagnosis ... #Allergy #Signs
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 Heat Illnesses and Heat Stroke - Differential Diagnosis Framework Heat Cramps: • Muscle pain or spasm -
- Differential Diagnosis ... blisters on the skin ... Collapse: • Pathophysiology ... → Syncope • Signs ... #causes #stroke
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... intralobular bile ducts causes ... failure PBC Signs ... Examination: • Skin ... Jaundice (later manifestation
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
chest (in a V-sign ... shoulders (in a shawl sign ... Muscle atrophy may cause ... Dermatomyositis #diagnosis ... #rheumatology #dermatology
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