9 results
CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
HIV-Associated CNS Opportunistic ... : • Most CNS opportunistic ... • CNS opportunistic ... - Generally >3 cm ... and <25% culture positive
Adult-Onset Still's Disease
Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia
+ Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
HBV, Coxsackie, CMV ... Muscular: normal CK ... Disease #diagnosis #management ... #treatment #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... +: Virus (EBV, CMV ... or biologics (CMV ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS

What Is IRIS?
	• A state of hyperinflammatory response that
previously diagnosed opportunistic ... of preexisting opportunistic ... keratitis, iritis • CMV ... • Treat for opportunistic ... Differential #Diagnosis #Management
Giant cell arteritis (GCA)

Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
(at least 1-2 cm ... Biopsies remain positive ... them, but urgent rheumatology ... Symptoms #Diagnosis #Management
IDSA Recommendations for Treating Cytomegalovirus Infections in HIV-AIDS
Preventing CMV Disease:
 • CMV end-organ disease is best
Disease: • CMV ... ART to maintain CD4 ... /mm3 Managing CMV ... Prevention #Treatment #management ... #opportunistic
IDSA Recommendations for Preventing and Treating Toxoplasma gondii Encephalitis in HIV-AIDS
Indications for Initiating Primary Prophylaxis:
 •
Toxoplasma IgG positive ... patients with CD4 ... Prevention #Treatment #opportunistic ... infections #HIVAIDS #management
IDSA Recommendations for Treating Coccidiodomycosis in HIV-AIDS
Treating Mild Infections (Such As Focal Pneumonia or asymptomatic patients
patients with positive ... serology and CD4 ... Prevention #Treatment #management ... #opportunistic
Anti-NXP-2 Dermatomyositis

What?
DM with generalized subcutaneous edema
Pts have more myalgias, more severe weakness, and an increased prevalence
without increasing CK ... NXP-2 antibody positive ... of anti-NXP-2-positive ... Dermatomyositis #diagnosis #management ... #rheumatology #