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diagnosis infections treatment syndrome differential hivaids idsa infectiousdiseases pharmacology prevention adultonset aids antinxp2 antinxp2dm behcet coccidiodomycosis cytomegalovirus dermatology dermatomyositis fungal
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
: • Most CNS opportunistic ... • CNS opportunistic ... Demyelinating disease ... - Generally >3 cm ... and <25% culture positive
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Adult-Onset Still's Disease ... HBV, Coxsackie, CMV ... Muscular: normal CK ... #diagnosis #management ... #treatment #rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
basal ganglia, CNS ... meningitis), MCC CNS ... Skin lesions • Positive ... Syndrome #diagnosis #management ... signs #symptoms #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
→Activation of CD8 ... +: Virus (EBV, CMV ... or biologics (CMV ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
worsening of that disease ... pleural effusions, CNS ... pericarditis, peritoneal disease ... keratitis, iritis • CMV ... Differential #Diagnosis #Management
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
/aggregate) of CD4 ... nervous system (CNS ... • 8%-27% for CNS ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
IDSA Recommendations for Treating Cytomegalovirus Infections in HIV-AIDS Preventing CMV Disease: • CMV end-organ disease is best
Disease: • CMV ... end-organ disease ... ART to maintain CD4 ... Prevention #Treatment #management ... #opportunistic
IDSA Recommendations for Treating Coccidiodomycosis in HIV-AIDS Treating Mild Infections (Such As Focal Pneumonia or asymptomatic patients
patients with positive ... serology and CD4 ... Extrathoracic Disseminated Disease ... Prevention #Treatment #management ... #opportunistic
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
NXP-2 antibody positive ... had more severe disease ... of anti-NXP-2-positive ... Dermatomyositis #diagnosis #management ... #rheumatology #
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
pulmonary symptoms • Rheumatologic ... especially the CNS ... MC: CNS CSF: • ... infection have positive ... Fungal #Diagnosis #Management
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