Rb checkpoint - GrepMed

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The Cell Cycle
The cell cycle is the series of tightly regulated steps that controls cell growth

Retinoblastoma (Rb ... Both Rb and p53 ... in the case of Rb ... through the G1/S checkpoint ... /S, S/G2, G2/M checkpoints

Lung Nodules - Differential Diagnosis by Distribution
• Centrilobular: Hypersensitivity Pneumonitis, RB-ILD, Pneumoconiosis, Infectious Bronchiolitis, Vasculitis,

Hypersensitivity Pneumonitis, RB-ILD

Upper lung zone preference is seen in:
- Inhaled particles: pneumoconiosis (silica or coal)
- Smoking related diseases

bronchiolitis (RB-ILD

Undifferentiated shock - Algorithm for the Evaluation of Hypotension. This process for the evaluation of hypotension

halting at evaluable checkpoints

Immune-related adverse events (irAE) of immune checkpoint inhibitors (ICI)

- By Antoine Briantais
Dr. Benjamin

irAE) of immune checkpoint

Interstitial Lung Diseases (ILD)
Exposure-Related ILD (a.k.a. extrinsic allergic alveolitis):
• Hypersensitivity pneumonitis, Farmer's lung, Bird

lung disease (RB-ILD

Myocarditis

5 Principles of
Myocarditis:
1. Build clinical suspicion
2. Decide on EMBx
3. Manage acute cardiac injury
4. Manage chronic

anti-metabolite - Immune Checkpoint

Check point inhibitors and Side Effects - Immune-related adverse events (IRAEs)

What are the side effects?
-

by stopping the checkpoint

Aortitis - Differential Diagnosis Framework
Non-Infectious Aortitis:
• Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,

Erdheim-Chester), Immune Checkpoint

Pulmonary complications of targeted therapy
-Immune checkpoint inhibitors (e.g. pembrolizumab)
-Pneumonitis is uncommon (~5% of patients) but can

therapy -Immune checkpoint

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