1206 results
Acute Rheumatic Fever: Pathogenesis and Clinical Findings

Delayed autoimmune reaction
-> Molecular mimicry
-> GAS antigen cross-reacts with host
->
Delayed autoimmune reaction ... Activation of auto-reactive ... RheumaticFever #pathophysiology
Pathogenesis of Rheumatic Fever

Pathogenesis of rheumatic fever. 
1. GAS pharyngitis leads to antigenic presentation of pathogenic
development of cross-reactive ... antibodies and cross-reactive ... activation' by cross-reactive ... Rheumatic #Fever #Pathophysiology
NSAIDS and their effects on the Kidney - Pathophysiology

Arachidonic Acid metabolites into alternative pathways that modify
on the Kidney - Pathophysiology ... Idiosyncratic immune reaction ... nephrology #Effects #pathophysiology
Anticonvulsants as Mood Stabilizers: Mechanism and Side-effect
Examples: Valproate, Carbamazepine, Lamotrigine
 • Mild anticholinergic effect -> Drowsiness
constipation • Allergic reaction ... mediated cytotoxic reaction ... #SideEffects #Pathophysiology
Reactive Arthritis
 • Inflammation of joints (commonly large joints)
    - Asymmetric Oligoarthritis: Joint
Reactive Arthritis ... ReactiveArthritis #pathophysiology
Allergic Rhinitis: Pathogenesis and clinical findings

1. Allergy Sensitization -> Antigen Exposure -> APC (macrophages, HLA class
Primary Reaction ... Secondary Reaction ... after the primary reaction ... Rhinitis #Rhinorrhea #pathophysiology
Systemic Lupus Erythematosus (SLE): Pathogenesis

 • Genetic factors (Mutations in HLA- DR2/HLA-DR3 genes, complement genes, cytokine
proteins) • Auto-reactive ... Erythematosus #SLE #Pathophysiology
Pseudogout: pathogenesis and clinical findings
 - Idiopathic (vast majority of cases) -> Mechanism unknown
 - Familial
Hypomagnesia -> The relative ... onset) - Incr C-reactive ... Signs #Symptoms #Pathophysiology
Anaphylaxis: Pathogenesis
Anaphylaxis is a Type 1 hypersensitivity reaction
While the primary mechanism of anaphylaxis is mast cell
hypersensitivity reaction ... #Anaphylaxis #pathophysiology
Raynaud’s Phenomenon: Pathogenesis and clinical findings
 • Finger pulp atrophy
 • Tissue ischemia/infarction -> Digital ulcerations
extremities • Reactive ... Raynauds #Phenomenon #pathophysiology