16 results
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Cerebrovascular Disease ... autoantibodies that will cause ... thrombosis and/or blood-brain ... #neurology #rheumatology ... #management #treatment
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY

RED FLAGS - In all cases there are specific
markers which
FLAGS - In all cases ... splenomegaly, abnormal neurology ... , back pain Haematology ... Pathway #Child #Peds ... #Pediatrics #Diagnosis
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
• Heavy Chain disease ... et diutinum Neurologic ... Sneddon-Wilkinson disease ... #Differential #Diagnosis ... #Oncology
Hearing Loss - Differential Diagnosis Framework

Hearing Loss Types:
• Conductive
• Sensorineural
• Mixed
Presbycusis is the most common type
Diagnosis Framework ... include a: • Neurologic ... auditory nerve (CN ... cause unknown) ... ○ HIV ○ Lyme disease
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
on bone marrow leading ... extramedullary disease ... involvement • 30%: CNS ... -> AML: Blast crises ... #Oncology #Diagnosis
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
life-threatening diseases ... Inflammatory eye disease ... Goodpasture's cause ... reveals increasing blood ... #management #treatment
Aortic Dissection Pearls
Aortic dissection is caused by a tear in the tunica intima, the innermost layer
dissection is caused ... • Aortic valve disease ... ~60 • Control blood ... Aortic #Dissection #diagnosis ... #management #vascular
Hepatic Encephalopathy - Diagnosis and Management Summary
Definition:
 • Alteration in brain function manifested by neuropsychiatric symptoms
and Management ... of neurologic/cognitive ... over course of disease ... #Management #treatment ... #hepatology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... membrane into the CNS ... deficiency • blood ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
ABO incompatible blood ... Thromboembolism (7%) • CNS ... • Severe Liver Disease ... #Coagulation #diagnosis ... #management #hematology