10 results
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... dosing and bridging ... Rivaroxaban #Edoxaban #Loading ... #DVT #Pharmacology ... #Hematology
Anticoagulant Bridging

 • Switching from LMWH
 • Switching from UFH
 • Switching from DOAC to Warfarin
Anticoagulant Bridging ... Warfarin to DOAC (No Bridging ... Kfischer_10 #Anticoagulant ... #pharmacology # ... management #hematology
Warfarin - INR Goals, Initial Dosing and Bridging

Mechanical Mitral Valve Replacement 2.5-3.5 
Other Valve Replacement 2-3
Replacement 2-3 VTE Treatment ... Alternatively, sometimes a loading ... VTE treatment), ... depletion of natural anticoagulants ... #Initiation #Pharmacology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
inflammation, leading ... Pathway - Aspirin, anticoagulants ... APS), Secondary prevention ... Erythematosus #SLE #CNS #neurology ... #rheumatology #
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
procedure Stop anticoagulant ... treatment; volume ... Reversal #NOAC #Oral #anticoagulant ... #hematology #management ... #pharmacology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
interactions) Cancer-treatment ... DOACs thereby leading ... metabolization leading ... Chemotherapy #Oncology #Hematology ... Interactions #Table #Pharmacology
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
Histology Findings (eg Bridging ... no great data regarding ... need for treatment ... Diagnosis #Management #Hepatology
Complications after Bariatric Surgery
Post Bariatric Intestinal Failure:
 • Severe protein malnutrition after bariatric surgery
 • More
nutrients • TPN for treatment ... inuslin release leading ... excluded limb • Treatment ... and prevention ... Gastroenterology and Hepatology
Hepatic Encephalopathy - Diagnosis and Management Summary
Definition:
 • Alteration in brain function manifested by neuropsychiatric symptoms
other causes of neurologic ... noxious stimuli) TREATMENT ... Initiate empiric treatment ... Encephalopathy #Grading ... #hepatology
Solitary Cell Plasmacytoma

What?
• Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma)
• In 3%
sometimes with thick ridging ... the periphery, creating ... Bone marrow Treatment ... Diagnosis #Workup #Hematology