10 results
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... Clotmaster #VTE #DOAC ... Rivaroxaban #Edoxaban #Loading ... #DVT #Pharmacology ... #Hematology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
) Cancer-treatment ... thereby leading ... metabolization leading ... Chemotherapy #Oncology #Hematology ... Interactions #Table #Pharmacology
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
anticoagulant treatment ... not available #DOAC ... #Oral #anticoagulant ... #hematology #management ... #pharmacology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
inflammation, leading ... permeability Diagnosis ... APS), Secondary prevention ... CNS #neurology #rheumatology ... #cerebritis #diagnosis
Eosinophilic Gastroenteritis: Treatment Options Based on Severity of the Disease
Mild:
 • Trial of PPI
 • Trial
Gastroenteritis: Treatment ... of PPI plus • Oral ... consultation for non-healing ... Concern for HES: • Hematology ... • Additional diagnostic
It is important to recognize Acute Decompensated Heart Failure (ADHF) as more than just simply a
emphasis placed on prevention ... causing hypovolemia needing ... transitioning to oral ... then placed on prevention ... icu #clinical #pharmacology
Complications after Bariatric Surgery
Post Bariatric Intestinal Failure:
 • Severe protein malnutrition after bariatric surgery
 • More
nutrients • TPN for treatment ... Tx: hydration, oral ... excluded limb • Treatment ... and prevention ... gastroenterology #diagnosis
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
Nephrogenic DI Hematologic ... Adenocarcinoma Treatment ... lubricants • Pharmacologic ... : • Severe oral ... Sjogrens #Syndrome #Rheumatology
IDSA Recommendations for Treating Mycobacterium Tuberculosis Infection and Disease in HIV-AIDS
Treating LTBI (to prevent TB disease)
Indications:
receiving an EFV- or RAL-based ... and molecular diagnostic ... Tuberculosis #TB #IDSA #Prevention ... #opportunistic ... infections #HIVAIDS #pharmacology
Solitary Cell Plasmacytoma

What?
• Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma)
• In 3%
mainly in the oral ... the periphery, creating ... Diagnosis? ... Bone marrow Treatment ... #Workup #Hematology