14 results
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
Clotmaster #VTE #DOAC ... Rivaroxaban #Edoxaban #Loading ... #DVT #Pharmacology ... #Hematology
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
) Cancer-treatment ... thereby leading ... metabolization leading ... Chemotherapy #Oncology #Hematology ... Interactions #Table #Pharmacology
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
DOAC Reversal Emergency ... anticoagulant treatment ... not available #DOAC ... anticoagulant #hematology ... #management #pharmacology
Behcet's Syndrome - Treatment
Ulcers:
 • Treatment: Topical steroids
 • Prevention: Colchicine
 • Azathioprine for refractory disease
Arthritis:
Behcet's Syndrome ... Topical steroids • Prevention ... Behcets #disease #Syndrome ... #pharmacology # ... rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... inflammation, leading ... Puncture, EEG Treatment ... APS), Secondary prevention ... CNS #neurology #rheumatology
Susac Syndrome - Clinical Triad
 - Central nervous system dysfunction
 - Branch retinal artery occlusion
 -
Susac Syndrome - ... Sensorineural hearing ... arterioles - Treatment ... David #Susac #Syndrome ... Diagnosis #Management #Rheumatology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation Syndrome ... IL-1 and IL-6, leading ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
Complications after Bariatric Surgery
Post Bariatric Intestinal Failure:
 • Severe protein malnutrition after bariatric surgery
 • More
Consider refeeding syndrome ... nutrients • TPN for treatment ... deficiencies) Dumping Syndrome ... excluded limb • Treatment ... and prevention
It is important to recognize Acute Decompensated Heart Failure (ADHF) as more than just simply a
emphasis placed on prevention ... causing hypovolemia needing ... acute coronary syndrome ... then placed on prevention ... icu #clinical #pharmacology
Clarkson’s Disease - Capillary leak syndrome
Epidemiology: Roughly 150 published cases, Median age 50 years, No sex
Capillary leak syndrome ... edema, compartment syndrome ... disease flares: • Prevention ... Capillary #leak #syndrome ... #rheumatology