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Essential Thrombocythemia (ET) ET is a chronic myeloproliferative neoplasm. Most cases are related to mutations that affect
MPL-thrombopoietin receptor ... PV, MDS, CML) Treatment ... • Treatment is ... Thrombocythemia #ET #hematology ... diagnosis #management #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Increased soluble IL-2 receptor ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
Central Nervous System Pharmacology - Somatic and Autonomic Receptors Somatic • Rocuronium -> Non-depolarizing (reversible competitive inhibitors)
and Autonomic Receptors ... Ach -> Nicotinic Receptor ... -> Muscarinic Receptor ... -> Adrenergic Receptor ... -> Adrenergic Receptor
Third Generation Antipsychotics: Mechanisms and Side Effects (Atypical Anti-Psychotics) Example: Aripiprazole Dopamine D2 Receptor Partial Agonist • Binds
Binds to the D2 receptor ... bind to the D2 receptor ... over-stimulating receptors ... Bind to 5-HT 1A receptor ... similar to D2-receptor
Second Generation Antipsychotics: Mechanisms and Side Effects (Atypical Anti-Psychotics) - Examples: Clozapine, Olanzapine, Quetiapine, Risperidone, Zotepine, Paliperidone,
Note: Receptor binding ... considered 2nd line treatment ... • Dopamine D2 Receptor ... • Serotonin 2A Receptor ... • Serotonin 2C Receptor
Receptor actions of sympathomimetic and dopaminergic agents. Adrenaline (epinephrine) Noradrenaline (norepinephrine) Isoprenaline Dopamine Dopexamine Dobutamine #Pharmacology #Vasopressors
Receptor actions ... #Vasopressors #Receptors
Hypereosinophilia and Hypereosinophilic Syndrome • Secondary Hypereosinophilic Syndrome • Clinically Relevant HES Variants • When to
suspect underlying hematologic ... Diagnosis and Treatment ... Syndrome #HES #Hematology
Algorithm for the Treatment of Uremic Pruritus Nonpharmacologic Treatments: • Daily topical emollient • Avoidance of extremes
Algorithm for the Treatment ... Nonpharmacologic Treatments ... • mu- opioid receptor ... antagonist/k-receptor ... ) • k-opioid receptor
Summary of the therapeutic uses of adrenergic agonists Table of Catecholamine Pressors, Non-Catecholamines, Alpha and Beta Receptor
Alpha and Beta Receptor ... NonCatecholamines #Receptors
Sedative-Hypnotic Drugs Benzodiazepines: - Bind to specific GABAA receptor subunits at central nervous system (CNS) neuronal synapses
specific GABAA receptor ... specific GABA-A receptor ... subgroup of GABAA receptors ... duration 5-HT-Receptor ... agonist at 5-HT receptors
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