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diagnosis hematology abnormal bruising intravascular prolonged anemia disseminated hemolysis hemostasis management pediatrics peds purpura thrombocytopenia treatment
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... coagulation (DIC ... hemoglobinuria (PNH) Extravascular ... #Hemolytic #Intravascular ... #Causes #differential
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Coagulation (DIC ... • Prolonged PT ... Fibrinogen: ↓ • PT ... INR < 2.3 - APTT ... #causes #treatment
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... PT and/or aPTT ... Disseminated intravascular ... coagulation (DIC ... #differential #
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... PT and the aPTT ... intravascularcoagulation (DIC ... #differential # ... hematology #coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... inhibitor of a coagulation ... coagulation, or ... discern these causes ... disease • Acute DIC
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... purpura - DIC ... (disseminated intravascular ... coagulation) ... pediatrics #diagnosis #differential
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