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diagnosis hematology pt abnormal bruising cardiology intravascular purpura thrombocytopenia algorithm cardiomyopathy dermatology disseminated elderly extravascular geriatrics hemolysis hemolytic hemostasis management
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
Causes of Prolonged ... (INR) - Bleeding ... (INR) - No Bleeding ... Differential #Diagnosis ... #disorders
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Pre-analytical cause ... (DIC) c. ... #Prolonged #Causes ... #diagnosis #differential
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Thrombocytopenia • Prolonged ... Treat primary cause ... - Hg > 7 - INR ... < 2.3 - APTT ... #diagnosis #causes
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... intravascularcoagulation (DIC ... #Prolonged #Causes ... #diagnosis #differential ... #hematology #coagulation
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential ... - History of bleeding ... INR/PT, aPTT(liver ... changes), high MCV anemia ... #Differential #
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Hemostasis - Differential ... inhibitor of a coagulation ... the PT remains prolonged ... discern these causes ... disease • Acute DIC
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... , coagulation disorders ... • Disruptions in ... disorders CAUSES ... - Hemolytic anemia
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... intravascular coagulation ... (DIC) - HELLP ... lymphoproliferative disorders ... #differential #
Causes of Purpura or Easy Bruising in Children Platelet count reduced, i.e. thrombocytopenia - Increased platelet destruction
Causes of Purpura ... Easy Bruising in ... purpura - DIC ... intravascular coagulation ... pediatrics #diagnosis #differential
Palpitations - Differential Diagnosis Framework What? • It is an unpleasant awareness or sensation that the heart is
Palpitations - Differential ... exam • 12-lead ECG ... Hyperthyroidism • Anemia ... Psychiatric: • Panic disorder ... straight after bending
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