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hematology abnormal algorithm bruising cardiology classification prolonged pt purpura thrombocytopenia bleeding cardiomyopathy chf cirrhosis deficiency dermatology endocrinology extravascular gout heartfailure
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... intravascular coagulation ... (DIC) - HELLP ... lymphoproliferative disorders ... #differential #
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... , coagulation disorders ... disorders CAUSES ... /TTP/HUS - Hemolytic ... anemia - Splenomegaly
High Output Heart Failure - Pathophysiology and Differential Diagnosis Obesity - Systemic Vasodilation, Vasoactive Adipokines Arteriovenous Fistula -
High Output Heart ... Systemic Vasdilation, AV ... Myeloproliferative Disorders ... Metabolism Severe Anemia ... #causes
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Pre-analytical cause ... (DIC) c. ... #Prolonged #Causes ... #diagnosis #differential
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... the PT and the aPTT ... intravascularcoagulation (DIC ... #diagnosis #differential ... #hematology #coagulation
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Diagnosis Algorithm ... • Bleeding • Hemolysis ... Chronic Disease (e.g ... Chronic Infection) High
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential ... : INR/PT, aPTT(liver ... psychiatric changes), high ... MCV anemia (vegan ... Diagnosis #Causes
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
malignancies • Anemia ... iron deficiency, hemolysis ... Chronic inflammatory disorders ... (e.g. autoimmune ... #Diagnosis #Causes
Causes of Iron Deficiency • Diet: ↓ Intake, e.g. vegan, Malnutrition, Polyphenol / tannins, ↓ Vitamin
Diet: ↓ Intake, e.g ... hepcidin) • Others: Hemolysis ... Iron metabolism disorders ... #differential # ... diagnosis #anemia
Causes of Anemia in Cirrhosis - Differential Diagnosis Framework LOW RETIC INDEX - ↓ PRODUCTION • Vitamin
Causes of Anemia ... Diagnosis Framework ... Inflammation NORMAL / HIGH ... anemia, Hemolysis ... Wilson's disease, DIC-low
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